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IL-1 beta Protein, Human (E6K, His)

MCE 站：IL-1 beta Protein, Human (E6K, His)

IL-1 beta 是一种强效促炎细胞因子，由单核细胞、巨噬细胞和树突状细胞表达，在炎症和免疫反应中起关键作用。IL-1 beta 以无活性的 pro-IL-1β (由 pro-Il-1b 编码) 形式产生，以响应炎症刺激。IL-1 beta Protein, Human (E6K, His) 由大肠杆菌表达产生，由 269 个氨基酸 (M1-S269) 组成，其 N 末端带有His 标签。

Synonyms: Interleukin-1 beta; IL-1β; IL1F2; IL-1 beta; IL1B

Species: Human

Source: E. coli

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized human IL1B at 10 μg/mL (100 μl/well) can bind human IL1R1 ａnd the EC₅₀ is 0.198 μg/mL.

研究背景：Interleukin-1β (IL-1β) is one of the pro-inflammatory cytokines ａnd is produced ａnd secreted by a variety of cell types although the vast majority of studies have focussed on its production within cells of the innate immune system, such as monocytes ａnd macrophages.
IL-1β is produced as inactive pro-IL-1β (encoded by pro-Il-1b) in response to inflammatory stimuli, including both microbial products ａnd endogenous danger-associated molecules. IL-1β gene expression ａnd synthesis of pro-IL-1β occurs after activation of pattern recognition receptors (PRRs). Inflammatory stimuli also drive activation of cytosolic CARD ａnd PYHIN domain-containing PRRs that recruit ASC ａnd caspase-1 (Casp-1) to assemble into the multiprotein complex inflammasome. Pro-Casp-1 (encoded by pro-Casp-1), activated by the inflammasome, cleaves pro-IL-1β into the bioactive IL-1β. IL-1β acts in an autocrine/paracrine manner via the type I IL-1 receptor (IL-1R1).
IL-1β could regulate the inflammatory response, ａnd is involved in a variety of cellular activities, including cell proliferation, differentiation, ａnd apoptosis. IL-1β also plays a significant regulator of reproduction in females.

蛋白编号：P01584 (M1-S269, E6K)

基因 ID：3553

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-1  |  白细胞介素-1 beta  |  细胞因子和生长因子  |  神经营养因子  |  白细胞介素-1  |  白细胞介素-1 beta

Categories：Cytokines ａnd Growth Factors  |  Interleukin & Receptors  |  IL-1  |  IL-1 beta  |  Cytokines ａnd Growth Factors  |  Neurotrophic Factors  |  IL-1  |  IL-1 beta

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