MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

IL-17RA Protein, Human (HEK293, hFc)

MCE 站：IL-17RA Protein, Human (HEK293, hFc)

IL-17RA (白细胞介素 17 受体 A) 是 IL-17A 和 IL-17F 的受体，是一种 I 型膜糖蛋白。它普遍表达并表现出广泛的组织分布，并在许多炎症和自身免疫性疾病中发挥作用。IL-17RA 是IL-17 家族其他成员的共同受体亚基。IL-17RA 与 IL-17RC 结合形成 IL-17A 和 IL-17F 的信号受体复合物。IL-17RA Protein, Human (HEK 293, hFc) 在 HEK293 细胞中产生，由 288 个氨基酸 (L33-W320) 组成，其 C 末端带有 hFc 标签。

Synonyms: CANDF5; CD217; CD217 antigen; CDw217; CTLA8; HIL 17R; hIL17R; I17RA_HUMAN; IL 17 receptor A; IL 17 receptor; IL 17RA; IL-17 receptor A; IL-17RA; IL17; IL17A receptor; IL17R; IL17RA; IMD51; Interleukin 17 receptor A; Interleukin-17 receptor A; MGC10262

Species: Human

Source: HEK293

Biological Activity: Measured by its ability to inhibit IL-17-induced IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The ED₅₀for this effect is 110-200 ng/mL in the presence of 10 ng/mL recombinant human IL-17, corresponding to a specific activity is ≥ 9074.4 U/mg.

研究背景：Interleukin-17 receptor A (IL-17RA), also known as CD217, is a cytokine receptor that binds interleukin 17. IL-17RA is a proinflammatory cytokine secreted by activated T-lymphocytes. IL-17 receptor family is composed of five members from IL-17RA to IL-17RE. The subunit IL-17RA is ubiquitous ａnd is a common co-receptor subunit for other members of the IL-17 family. The IL-17RA gene is mapped to human chromosome 22q11.1 ａnd is expressed ubiquitously ａnd exhibits a broad tissue distribution.
The amino acid sequence of human IL17RA protein has low homology between mouse ａnd rat IL-17A protein.
IL-17A, the prototypic T helper 17 (Th17) cytokine, is important in host defense at mucosal surfaces, but also functions as an important inflammatory mediator involved in the pathogenesis of many autoimmune diseases, including rheumatoid arthritis (RA). IL-17RA pairs with IL-17RC to bind either IL-17A or IL-17F as covalent homodimers, but also IL-17A/IL-17F as heterodimers. IL-17RA offers protection against pathogenic infection as it plays an important role in host defence mechanism. IL-17A activates downstream cellular signaling through IL-17 receptor (IL-17R) complex comprised of the IL-17A receptor (IL-17RA) ａnd IL-17C receptor (IL-17RC) subunits with higher affinity to IL-17RA. The IL-17A/IL-17RA axis has been implicated in the pathogenesis of several acute ａnd chronic airway ａnd lung diseases. However, the association of IL-17RA with other members of the IL-17 receptor family shifts the affinity toward other members of the IL-17 family. Indeed, combination of IL-17RA with IL-17RB binds IL-17E as covalent homodimers. Besides, IL-17RA can also associate with IL-17RE to bind IL-17C as homodimers. However, the involvement of IL-17RA is not compulsory, as IL-17RB forms homodimers to target IL-17B as covalent homodimers.
IL-17RA play a pathogenic role in many inflammatory ａnd autoimmune diseases such as rheumatoid arthritis. IL-17RA involved in antimicrobial host defense ａnd maintenance of tissue integrity. It has been demonstrated in infectious models in which neutrophils are crucial for host defense, that IL-17RA deficiency results in reduced chemokine levels ａnd reduced neutrophil numbers, ａnd increased susceptibility to infection. In addition, IL-17RA is expressed by diverse intestinal cell types, ａnd therapies targeting IL-17A induce adverse intestinal events, suggesting additional tissue-specific functions. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5). IL17RA deficiency might lead to the risk of chronic mucocutaneous candidiasis.

蛋白编号：Q96F46 (L33-W320)

基因 ID：23765

产品分类：细胞因子和生长因子  |  白细胞介素  |  白介素-17 受体  |  白介素-17 受体 A  |  CD 抗原  |  上皮细胞 CD 蛋白  |  CD217  |  CD 抗原  |  内皮细胞 CD 蛋白  |  CD217

Categories：Cytokines ａnd Growth Factors  |  Interleukin & Receptors  |  IL-17 Receptor  |  IL-17RA  |  CD Antigens  |  Epithelial cell CD Proteins  |  CD217  |  CD Antigens  |  Endothelial cell CD Proteins  |  CD217

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。