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AITRL/TNFSF18 Trimer Protein, Human (Biotinylated, HEK293, His-Flag)

MCE 站：AITRL/TNFSF18 Trimer Protein, Human (Biotinylated, HEK293, His-Flag)

AITRL，一种 II 型跨膜蛋白，是糖皮质激素诱导的 TNFR 相关蛋白 (GITR) 的配体。当 AITRL 与 GITR 结合时，GITR 可以产生调节 T 细胞增殖和效应子功能的共刺激信号。GITR/GITRL 相互作用在肿瘤、炎症以及自身免疫性疾病的发病中发挥着重要作用。此外，AITRL 还在内皮细胞 (ECs) 的激活中发挥作用，并促进小鼠和人类细胞的粘附，从而增加 STAT-1 磷酸化和粘附分子 (如 VCAM-1 和 ICAM-1) 的表达。AITRL/TNFSF18 Protein, Human (Biotinylated, HEK293, His-Flag) 是一种重组生物素化的人 AITRL (Q72-S199)，其 N 端带有 His 和 Flag 标签，在 HEK293 中表达。

Synonyms: TNFSF18; AITRL; TL6; GITRL; GITR Ligand

Species: Human

Source: HEK293

Biological Activity: 1.Immobilized Human GITR His at 1 μg/mL (100 μL/Well). Dose response curve for Biotinylated Human GITR Ligand Trimer His with the EC₅₀ of 0.2 μg/mL determined by ELISA.
2.Immobilized Human GITR His at 5 μg/mL (100 μL/Well). Dose response curve for Biotinylated Human GITR Ligand Trimer His with the EC₅₀ of 1.69 μg/mL determined by ELISA.

研究背景：GITRL (AITRL), a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). GITR, a member of the TNFR superfamily, is expressed in T cells, natural killer cells ａnd some myeloid cells. And GITRL is mainly expressed on antigen presenting cells (B cells, dendritic cells), macrophages ａnd endothelial cells (ECs).
When GITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation ａnd effector functions. The interaction stimulates proliferation ａnd cytokine production of both CD4⁺ Teff ａnd Treg cells, ａnd drives antitumor activity of CD8⁺ T cells. Besides, GITRL plays a role in EC-activation ａnd promotes adhesion in both mice ａnd humans, which increases STAT-1 phosphorylation ａnd the augmented expression of adhesion molecules such as VCAM-1 ａnd ICAM-1.
Human GITRL shares < 55% common aa identity with mouse. Human GITRL consists of cytoplasmic domain (M1-W27), helical domain (L28-F48), ａnd extracellular domain (L49-S177). Human GITRL is a trimer, but can also be a monomer or assemble in other multimeric structures.
GITR/GITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases.

蛋白编号：Q9UNG2 (Q50-S177)

基因 ID：8995

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子配体  |  糖皮质激素诱导的 TNF 受体配体  |  生物素标记蛋白

Categories：Cytokines ａnd Growth Factors  |  TNF Superfamily  |  TNF Superfamily Ligands  |  GITRL/AITRL  |  Biotinylated Proteins

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