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4-1BB/TNFRSF9 Protein, Human (163a.a, HEK293, His)

MCE 站：4-1BB/TNFRSF9 Protein, Human (163a.a, HEK293, His)

4-1BB (CD137; TNFRSF9)，是 TNFSF9/4-1BBL 的受体，属于肿瘤坏死因子 (TNF) 受体超家族。4-1BB 有助于T细胞的激活和发育，还诱导外周单核细胞增殖、向肿瘤微环境迁移。4-1BB 也参与增强 Nrf2 和 NF-κB 通路介导的内皮细胞凋亡。人的 4-1BB 蛋白是一种表面糖蛋白，具有一个跨膜结构域 (187-213 a.a.)。重组人 4-1BB/TNFRSF9 蛋白 (163a.a, HEK293, His) 是 4-1BB 蛋白的胞外部分 (L24-Q186)，由 HEK293 细胞表达，带有 C 端 6*His 标签。

Synonyms: CD137; ILA; TNFRSF9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA

Species: Human

Source: HEK293

Biological Activity: 1.Loaded Human 4-1BB-His on HIS1K Biosensor, can bind Anti-Human CD137 mAb-Fc with an affinity constant of 25.5 nM as determined in BLI assay.
2.Immobilized Human 4-1BB-His at 10 μg/mL (100 μl/well) can bind Human 4-1BBL-Fc.The ED₅₀ of Human IL-23-His is 1.61 μg/mL.

研究背景：4-1BB, is encoded by TNFRSF9 (CD137, ILA), belongs to tumor necrosis factor (TNF) receptor superfamily. 4-1BB is a surface glycoprotein, expressed in a variety of cells, for example, T cells, B cells, natural killer (NK) cells, dendritic (DCs), eosinophils, ａnd mast cells; even a variety of tumor cells such as human leukemia cells. It is widely spread in vascular smooth muscles, tumor vessel walls, ａnd liver tissue of hepatocellular carcinoma. 4-1BB has a preference on CD8+ cells rather than CD4+ cells. It provides co-stimulatory signals ａnd activates cytotoxic effects of CD8+ T cells ａnd helps to form memory T cells. Finally, it promotes the immune system fighting against tumors. Moreover, CD137 binds CD137L to signal monocytes, increase their survival, proliferation ａnd stimulate their migration ａnd extravasation. In addition, it induces the release of various proinflammatory factors, leads to the influx of inflammatory monocytes into tissues ａnd form an inflammatory environment. Specifically, CD137 promotes the migration of monocytes/macrophages to tumor microenvironment by upregulating the expression of Fra1. It also promoted the differentiation of monocytes/macrophages into osteoclasts at the same time, thus providing a favorable microenvironment for the colonization ａnd growth of breast cancer cells in bone. It provides a promising therapeutic strategy for metastasis of breast cancer. Furthermore, CD137 signaling promotes endothelial cells (ECs) apoptosis through prooxidative ａnd proinflammatory mechanisms, mediated by Nrf2 ａnd NF-κB pathways, respectively. The homology of 4-1BB protein in human ａnd mouse was low, ａnd the sequence similarity was 56.75%.

蛋白编号：Q07011 (L24-Q186)

基因 ID：3604

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子受体  |  4-1BB  |  CD 抗原  |  T 细胞 CD 蛋白  |  4-1BB/CD137  |  CD 抗原  |  巨噬细胞 CD 蛋白  |  4-1BB/CD137  |  CD 抗原  |  干细胞 CD 蛋白  |  4-1BB/CD137  |  CD 抗原  |  树突细胞 CD 蛋白  |  4-1BB/CD137  |  免疫检查点蛋白  |  刺激性免疫检查点

Categories：Cytokines ａnd Growth Factors  |  TNF Superfamily  |  TNF Receptor Superfamily  |  4-1BB  |  CD Antigens  |  T Cell CD Proteins  |  4-1BB/CD137  |  CD Antigens  |  Macrophage CD Proteins  |  4-1BB/CD137  |  CD Antigens  |  Stem Cell CD Proteins  |  4-1BB/CD137  |  CD Antigens  |  Dendritic Cell CD Proteins  |  4-1BB/CD137  |  Immune Checkpoint Proteins  |  Stimulatory Immune Checkpoint Molecules

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