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IFN-alpha 2a/IFNA2 Protein, Human (R46K)

MCE 站：IFN-alpha 2a/IFNA2 Protein, Human (R46K)

IFN-alpha 2 (IFNA2)属于I型干扰素家族，是病毒感染的细胞分泌的一种蛋白质，作用于其他细胞并抑制病毒感染。IFN-alpha 2对CD8⁺ T细胞具有细胞毒性，能够诱导CD4⁺ T细胞耗损增加。重组人IFN-alpha 2a/IFNA2蛋白(C24-E188, R46K)全长165个氨基酸，由E. coli产生，不带标签。

Synonyms: rHuIFN-α2a; IFNA; IFNA2; IFN-a 2a

Species: Human

Source: E. coli

Biological Activity: The ED₅₀ is <0.16 ng/mL as measured by TF-1 cells, corresponding to a specific activity of >6.6 × 10⁶ units/mg.

研究背景：IFN-alpha 2 (IFNA2; IFN-α2), belongs to the type I interferon family, produced by the plasmacytoid dendritic cells (pDCs) exposure to HIV-1BaL in order to inhibit viral infection.
Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β ａnd related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) ａnd type III IFNs (IFN-λ), respectively.
IFN-alpha 2 subtype is the only one that is currently licensed to treat infections caused by hepatitis B virus (HBV) ａnd HCV.
IFN-alpha 2 shows a Sortilin-dependent trafficking in cells ａnd increases the expression level of interferon-stimulated genes (ISGs) in HIV-infected cells. It also exhibits cytotoxic activity against CD8⁺ T cells ａnd enhances CD4⁺ T cell depletion.
Among the IFN-alpha 2 alleles, IFN-alpha 2b is being the predominant allele while IFNα-2a is less predominant ａnd IFNα-2c only a minor allelic variant.
IFN-alpha 2 has a bored application in research of cancer, including some hematological malignancies ａnd solid tumors. As for a wildly use of IFN in animal disease model, the sequence of amino acids in IFNA2a protein of human is very different from mouse (59.57%).

蛋白编号：P01563 (C24-E188, R46K)

基因 ID：3440

产品分类：细胞因子和生长因子  |  干扰素  |  干扰素 α  |  干扰素-α2a

Categories：Cytokines ａnd Growth Factors  |  Interferon & Receptors  |  IFN-alpha  |  IFN-alpha 2a

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