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RANKL/TNFSF11 Protein, Human (HEK293)

MCE 站：RANKL/TNFSF11 Protein, Human (HEK293)

RANKL (TNFSF11)，一种 II 型跨膜蛋白，是 NF-κB 受体激活剂 (RANK) 的配体。RANKL 是 RANK 激活剂，当与 RANK 结合后，其诱导单核细胞/巨噬细胞谱系细胞分化为破骨细胞，并进一步导致破骨细胞前体成熟。因此，RANKL 对于破骨细胞成熟、骨骼建模和骨骼重塑，以及淋巴结 (LN) 的发育至关重要。RANKL/TNFSF11 Protein, Human (HEK293) 是一种由 HEK293 产生的重组人RANKL (G64-D245)，N 端不带标签。

Synonyms: Tumor necrosis factor ligand superfamily member 11; RANKL; CD254; ODF; OPGL; TNFSF11; TRANCE

Species: Human

Source: HEK293

Biological Activity: 1.Immobilized human TNFSF11 at 2 μg/mL (100 μL/well) can bind human Osteoprotegerin-hFc ａnd the EC₅₀ is 5-40 ng/mL.
2. Measured by its ability to induce TRAP activity, inducing osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The ED₅₀for this effect is 1.5-19.69 ng/mL, corresponding to a specific activity is > 5.079×10^4 units/mg.

研究背景：RANKL (TNFSF11) belongs to TNF family. RANKL is a type II transmembrane protein ａnd is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of NF-κB. RANKL binds to NF-κB ａnd induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts ａnd leads to osteoclast precursor maturation. In bone tissue, RANKL is expressed by osteoblasts, osteocytes ａnd immune cells, especially in osteoblasts ａnd osteocytes. RANKL is also expressed by T cells ａnd increases proliferation ａnd survival of dendritic cells.
Human RANKL shares 82.02% ａnd 84.44% common aa identity with mouse ａnd rat respectively. Human RANKL consists of cytoplasmic domain (1-47), helical domain (48-68), ａnd extracellular domain (69-317). The soluble chain (140-317) is released when cleaved by enzymes such as matrix metalloproteinases (MMP3 or 7) ａnd ADAM.
RANKL is critical for osteoclasts maturation, bone modeling, ａnd bone remodeling, as well as the development of lymph nodes (LNs).

蛋白编号：AAC51762.1 (G64-D245)

基因 ID：8600

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子配体  |  核因子-κB 受体激活因子配体  |  CD 抗原  |  T 细胞 CD 蛋白  |  RANKL/CD254  |  CD 抗原  |  巨噬细胞 CD 蛋白  |  RANKL/CD254

Categories：Cytokines ａnd Growth Factors  |  TNF Superfamily  |  TNF Superfamily Ligands  |  RANKL  |  CD Antigens  |  T Cell CD Proteins  |  RANKL/CD254  |  CD Antigens  |  Macrophage CD Proteins  |  RANKL/CD254

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