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Fas Ligand Protein, Human (HEK293, His)

MCE 站：Fas Ligand Protein, Human (HEK293, His)

Fas Ligand (CD178;APTL)是TNFRSF6/FAS/CD95的配体，转导凋亡信号以调节细胞毒性T细胞介导的凋亡，自然杀伤细胞介导的凋亡和T细胞发育。人源Fas Ligand具有4种亚型，其中可溶形式(130-281 a.a.)在T淋巴Jurkat细胞的活化诱导细胞死亡(AICD)中起重要作用。而Fas Ligand的膜结合亚型则负责其炎症活性。重组人Fas配体(HEK293, His)全长148个氨基酸(P134-L281)，由HEK293细胞表达，带有N端6*His标签。

Synonyms: Tumor necrosis factor ligand superfamily member 6; APTL; CD95-L; Fas ligand; FasL; CD178; TNFSF6

Species: Human

Source: HEK293

研究背景：Fas Ligand (FasL; FASLG; CD95L), is a ligand for TNFRSF6/FAS belonging to the tumor necrosis factor (TNF). FasL is a type II transmembrane protein, riggering apoptosis of lymphocytes.
FasL is expressed on a variety of cell types, including T cells, natural killer (NK) cells, monocytes, neutrophils, breast epithelial cells, ａnd vascular endothelial cells.
FasL exerts different biological activity by cleaved into 4 isoforms including membrane form, soluble form, ADAM10-processed FasL form (APL) ａnd SPPL2A-processed FasL form(SPA). Among them, the membrane-bound form ａnd a soluble form generated by proteolytic action of matrix metalloproteinases (MMP).
FasL or soluble FasL binding to Fas results in receptor aggregation ａnd in the interaction of a protein called Fas-associated death domain with the Fas cytoplasmic tail. The interaction triggers a cascade of intracellular events, including the activation of the IL-1-converting enzyme-like cysteine protease (caspase 8), that ultimately leads to nucleoprotein cleavage, DNA fragmentation, ａnd cell apoptosis.
The loss of function due to mutations in murine FasL, murine Fas, human Fas, or human FasL leads to lymphoproliferation, lymphadenopathy, ａnd autoimmune diseases.
Meanwhile, defective activation-induced cell death (AICD) results in spontaneous mutation of Fas ａnd FasL genes in mice with lupus-like autoimmune disease.
Human FasLigand also involves in Jurkat cell apoptosis ａnd binds TNFRSF6B/DcR3 to bolck apoptosis, which is a decoy receptor of apoptosis termination.
FasL is widely found in different animals, while the sequence in Human is different from Rat ａnd Mouse with similarity of 77.26% ａnd 78.06%, respectively.

蛋白编号：P48023 (P134-L281)

基因 ID：356

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子配体  |  Fas 配体  |  CD 抗原  |  T 细胞 CD 蛋白  |  CD178/FasL  |  CD 抗原  |  NK 细胞 CD 蛋白  |  CD178/FasL  |  CD 抗原  |  上皮细胞 CD 蛋白  |  CD178/FasL  |  CD 抗原  |  内皮细胞 CD 蛋白  |  CD178/FasL

Categories：Cytokines ａnd Growth Factors  |  TNF Superfamily  |  TNF Superfamily Ligands  |  Fas Ligand (FasL)  |  CD Antigens  |  T Cell CD Proteins  |  CD178/FasL  |  CD Antigens  |  NK Cell CD Proteins  |  CD178/FasL  |  CD Antigens  |  Epithelial cell CD Proteins  |  CD178/FasL  |  CD Antigens  |  Endothelial cell CD Proteins  |  CD178/FasL

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