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ANGPTL4/Angiopoietin-related 4 Protein, Human (HEK293, His)

MCE 站：ANGPTL4/Angiopoietin-related 4 Protein, Human (HEK293, His)

Angiopoietin-like protein 4, Human通过抑制脂蛋白脂肪酶 (LPL) 调节循环甘油三酯 (TG) 的分布。Angiopoietin-like protein 4是一种传统的，非竞争性的LPL 抑制剂。

Synonyms: rHuAngiopoietin-Related Protein 4, His; ANGPTL4; Angiopoietin-Related Protein 4

Species: Human

Source: HEK293

研究背景：Angiopoietin-like proteins (ANGPTLs) represent a family of eight secreted glycoproteins that show structural homology to angiopoietins ａnd carry distinct physiological functions, including putative roles in lipid metabolism, expansion of stem cells, inflammation, tissue remodeling ａnd angiogenesis. In recent years, three ANGPTLs, ANGPTL3, ANGPTL4 ａnd ANGP-TL8, have been shown to play a role in lipid metabolism ａnd in the regulation of plasma lipid levels. ANGPTL4 ａnd ANGPTL8 form a complex when refolded together ａnd that ANGPTL4 in that complex loses its ability to inactivate LPL. Angiopoietin-like protein 4 (ANGPTL4) is a secreted 50 kD protein that modulates the disposition of circulating triglycerides (TG) by inhibiting lipoprotein lipase (LPL). ANGPTL4 is a positive acute phase protein ａnd its increase could contribute to the hypertriglyceridemia that characteristically occurs during the acute phase response by inhibiting LPL activity.

蛋白编号：Q9BY76 (P166-S406)

基因 ID：51129

产品分类：细胞因子和生长因子  |  血管生成素家族  |  血管生成素样蛋白 4

Categories：Cytokines ａnd Growth Factors  |  Angiopoietins  |  Angiopoietin Like 4

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