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ANGPTL3/Angiopoietin-like 3 Protein, Human (204a.a, HEK293, His)

MCE 站：ANGPTL3/Angiopoietin-like 3 Protein, Human (204a.a, HEK293, His)

ANGPTL3/Angiopoietin-like 3 Protein, Human (204a.a, HEK293, His)在脂蛋白代谢中期重要作用。Angiopoietin-like Protein 3是脂蛋白脂肪酶 (LPL) 和内皮脂肪酶 (EL) 的双重抑制剂。Angiopoietin-like Protein 3抑制内皮脂肪酶水解HD-磷脂 (PL)，从而提高HDL-PL水平。

Synonyms: rHuAngiopoietin-like Protein 3, His; ANGPTL3; Angiopoietin-like Protein 3

Species: Human

Source: HEK293

Biological Activity: Immobilized Human at ANGPTL3 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Human ANGPTL3 Antibody, the ED₅₀ of human ANGPTL3 protein is 2.741 ng/mL, corresponding to a specific activity is 3.6483×10^5 units/mg.

研究背景：Angiopoietin-like proteins (ANGPTLs) represent a family of eight secreted glycoproteins that show structural homology to angiopoietins ａnd carry distinct physiological functions, including putative roles in lipid metabolism, expansion of stem cells, inflammation, tissue remodeling ａnd angiogenesis. In recent years, three ANGPTLs, ANGPTL3, ANGPTL4 ａnd ANGP-TL8, have been shown to play a role in lipid metabolism ａnd in the regulation of plasma lipid levels. The discovery of ANGPTL3 deficiency in mice ａnd humans has stimulated a series of studies which have clarified the role of ANGPTL3 in lipoprotein metabolism. These investigations have suggested that ANGPTL3 may be a novel therapeutic target in the management of dyslipidemias in humans. The results of recent intervention trials aimed at inhibiting ANGPTL3 appear to support this hypothesis.

蛋白编号：Q9Y5C1 (S17-P220)

基因 ID：27329

产品分类：细胞因子和生长因子  |  血管生成素家族  |  血管生成素样蛋白 3

Categories：Cytokines ａnd Growth Factors  |  Angiopoietins  |  Angiopoietin Like 3 Proteins

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