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TNF RII/TNFRSF1B Protein, Mouse (HEK293, His)

MCE 站：TNF RII/TNFRSF1B Protein, Mouse (HEK293, His)

TNFRII (TNFRSF1B) 蛋白具有与肿瘤坏死因子-α (TNF-α) 高度结合的能力。TNFRII 具有促凋亡作用。TNFRII 招募 TRAF2，诱导基因表达并与 TNFRI 进行密集串扰。TNFRII 选择性地增强死亡受体 TNFRII 诱导的细胞凋亡。TNF RII/TNFRSF1B Protein, Mouse (236a.a, HEK293, His) 由 HEK293 细胞表达，具有跨膜区 (V23-G258)，C 端带有 6*His 标签。

Synonyms: Tumor necrosis factor receptor superfamily member 1b; Tnfrsf1b; TNF-RII; TNFRII; TNF RII

Species: Mouse

Source: HEK293

Biological Activity: Measured by its ability to inhibit TNFα-mediated cytotoxicity in L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D.The ED₅₀ for this effect is typically 0.4-3 μg/mL in the presence of 0.1 ng/mL of recombinant mouse TNFα.

研究背景：TNFRII (TNFRSF1B) protein is a single-pass type I membrane protein belonging to the tumor necrosis factor (TNF) family. TNFRII is the major signaling receptor for TNF-α. TNFRII protein is highly regulated ａnd typically found in immune system cells.
The amino acid sequence of mouse TNFRII protein has low homology between human ａnd rhesus macaque TNFRII protein (less than 85%).
TNFRII induces apoptosis. TNFRII does not directly engage the apoptotic program, but relies on the induction of endogenous, membrane-bound TNF, which subsequently activates TNFRI. TNFRII stimulates the action of the endogenously produced membrane-bound TNF on TNFRI is drastically enhanced. TNFRII competes with TNFRI for the recruitment of newly synthesized TRAF2-bound anti-apoptotic factors, thereby promoting the formation of a caspase-8-activating TNFRI complex. TNFRII competes with TNFRI for binding of TRAF2 ａnd the TRAF2-associated anti-apoptotic cIAP1 ａnd cIAP2 proteins. cIAP1-initiated degradation of TRAF2, which in turn enhances receptor competition for the remaining TRAF2, cIAP1 ａnd cIAP2 molecules. cIAP1 would have an anti-apoptotic function upon recruitment into the TNFRI signalling complex, but would switch to a net proapoptotic function upon recruitment into the TNFRII signalling complex.

蛋白编号：P25119/NP_035740.2 (V23-G258)

基因 ID：21938

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子受体  |  肿瘤坏死因子受体 2  |  CD 抗原  |  上皮细胞 CD 蛋白  |  TNF-R2/CD120b  |  CD 抗原  |  内皮细胞 CD 蛋白  |  TNF-R2/CD120b

Categories：Cytokines ａnd Growth Factors  |  TNF Superfamily  |  TNF Receptor Superfamily  |  TNF Receptor 2 (TNF-R2)  |  CD Antigens  |  Epithelial cell CD Proteins  |  TNF-R2/CD120b  |  CD Antigens  |  Endothelial cell CD Proteins  |  TNF-R2/CD120b

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