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FGF basic/bFGF Protein, Human (145a.a, His)

MCE 站：FGF basic/bFGF Protein, Human (145a.a, His)

FGF-2/bFGF 是成纤维细胞因子家族的成员，参与骨的愈合、软骨修复、骨修复和神经再生。FGF-2 也是一种有丝分裂促进剂，能加速细胞增殖。FGF-2 通过特异性靶向酪氨酸激酶受体，激活 FGF/FGFR 信号通路来调控免疫过程。例如，FGF-2 参与 JAK-STAT 信号通路来调控软骨代谢，也激活 ERK 信号促进软骨再生。FGF-2 结合 FGFR1/3 分别促进关节软骨的退化和修复。FGF-2 还是 GBM 中已知的致癌因子，有助于胶质瘤生长、血管化。重组人碱性 FGF-2/bFGF 蛋白 (145a.a, His)，是由 E.coli 大肠杆菌产生的重组蛋白，全长 145 个氨基酸，带有 N 端 His 标签。

Synonyms: rHubFGF, 145a.a.; bFGF; FGF-2; HBGF-2; FGFB

Species: Human

Source: E. coli

Biological Activity: Measured in a cell proliferation assay using NIH-3T3 mouse fibroblast cells.The ED₅₀ for this effect is 0.1828 ng/mL, corresponding to a specific activity is 5.47×10⁶ units/mg.

研究背景：FGF-2/bFGF is a member of the fibroblast family ａnd has a high affinity for heparin. FGF-2 plays an important role in tendon to bone healing, cartilage repair, bone repair, ａnd nerve regeneration. FGF-2 specifically binds to tyrosine kinase receptors ａnd activates the FGF/FGFR signaling pathway. Subsequently, FGF-2 influences cell proliferation, differentiation ａnd apoptosis, as well as immune regulation by transducing other classical pathways. For example, FGF-2 regulates the JAK-STAT signaling pathway to regulate cartilage metabolism. FGF-2 also acts as a mitotic promoter to accelerate cell proliferation. Therefore, (1) FGF-2 is an important growth factor in the healing process of ligament/tendon injury. In vitro experiments, low-dose FGF-2 can stimulate the proliferation ａnd differentiation of bone marrow mesenchymal stem cells, ａnd up-regulate the mRNA expression of type I/III collagen ａnd fibronectin. However, high doses of FGF-2 did not stimulate extracellular matrix (ECM) protein proliferation ａnd gene expression. (2) FGF-2 is also an endogenous ａnd intrinsic growth factor in cartilage repair. FGF-2 binds to heparan sulfate proteoglycan ａnd is stored in the ECM of articular cartilage. When cartilage is damaged or degenerated, ECM rapidly releases FGF-2 ａnd activates ERK signaling pathways to promote cartilage regeneration. FGF-2 exhibits a biphasic effect in combination with its specific receptor. FGF-2 combined with FGFR3 promoted the repair of articular cartilage. FGF-2 combined with FGFR1 promoted the degeneration of articular cartilage. FGF-2 is expressed in granulosa cells ａnd colliculus cells, as well as hepatocellular cancer cells, but not in non-cancerous liver tissues. This reveals the role of FGF-2 in brain tumors, particularly glioblastoma. According to studies, FGF-2 is a known carcinogenic factor in GBM. FGF-2 increases the self-renewal of glioblastoma stem cells ａnd contributes to the growth ａnd vascularization of glioma. FGF-2 protein is highly conserved in some species, ａnd the similarity rate of human FGF-2 protein sequence to rat, mouse, ａnd bovine was 97.4%, 95.45%, ａnd 98.71%, respectively.

蛋白编号：P09038-4 (A144-S288)

基因 ID：2247

产品分类：细胞因子和生长因子  |  FGF 家族  |  成纤维细胞生长因子  |  成纤维细胞生长因子 2

Categories：Cytokines ａnd Growth Factors  |  FGF Family  |  Fibroblast Growth Factor  |  FGF-2/bFGF

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