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Acetyl Gastric Inhibitory Peptide (human) (TFA)

CAS No. :

MCE 站：Acetyl Gastric Inhibitory Peptide (human) (TFA)

产品活性：Acetyl Gastric Inhibitory Peptide (human) TFA 是葡萄糖依赖性的胰岛素性多肽的脂肪酸衍生类似物，具有改善的抗高血糖和胰岛素性。Acetyl Gastric Inhibitory Peptide (human) TFA 可用于糖尿病、胰岛素抵抗和肥胖的研究。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：Insulin Receptor

In Vitro: Acetyl Gastric Inhibitory Peptide (human) TFA induces cyclic adenosine 3＇5＇ monophosphate (cAMP) production with an EC₅₀ value of 1.9 nM in Chinese hamster lung fibroblast cells transfected with the human GIP receptor.
Acetyl Gastric Inhibitory Peptide (human) TFA (10^-13-10^-8 nM) shows potent effect at stimulating insulin release compared to the native GIP in BRIN-BD11 cells.
Acetyl Gastric Inhibitory Peptide (human) TFA improves glucose intolerance, type 2 diabetes, beta-cell glucose insensitivity, insulin resistance ａnd reduced insulin secretion.
Acetyl Gastric Inhibitory Peptide (human) TFA has metabolic stability ａnd hypoglycemic ａnd insulin modulating activities of two fatty acid derivatized N-terminally acetylated GIP analogs were evaluated in in vitro ａnd in vivo.

In Vivo: Acetyl Gastric Inhibitory Peptide (human) TFA (25 nmol/kg; i.p.; single dose) shows resistance to plasma dipeptidylpeptidase IV degradation, resulting in enhanced biological activity ａnd improved antidiabetic potential in vivo.

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