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IL-10R beta Protein, Human (HEK293, His)

MCE 站：IL-10R beta Protein, Human (HEK293, His)

IL-10R beta 蛋白是 IL10 细胞因子表面受体，参与 IL10 介导的炎症及免疫调控，以及病毒的防御反应。IL-10R beta Protein, Human (HEK293, His) 是由 HEK 293 细胞表达的，具有跨膜区 (W221-F242) ，C 端带有 6*His 标签。

Synonyms: Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b

Species: Human

Source: HEK293

Biological Activity: Immobilized Recombinant Human IL 28 R alpha /IFN lambda R1 at 5 μg/mL (100 μL/well) can bind Biotinylated Recombinant Human IL-10R beta. The ED₅₀ for this effect is 9.714 μg/mL.

研究背景：IL-10 receptor complex consists of a heterodimer of four transmembrane chains, two of which form IL-10R alpha ａnd two of which form IL-10R beta. IL-10R beta, originally known as the orphan receptor CRF2-4, is an essential accessory subunit for the active interleukin 10 receptor complex.
IL-10R beta can bind to IL-10 via the JAK-STAT pathway, ａnd activation of the IL-10 receptor complex leads to phosphorylation of the receptor-associated proteins TYK ａnd JAK-1, ａnd ultimately to activation of the transcription factors STAT3, STAT1, ａnd STAT5, which regulate the expression of IL-10-responsive genes, including c-myc, bcl-2, ａnd bcl-xL, initiating signal transduction.
IL-10R beta is expressed on most cell types ａnd is also a shared cell surface receptor required for the activation of five class II cytokines (IL-10, IL-22, IL-26, IL-28 ａnd IFNL1), which play a key role in host defense, immune regulation. Among them, the IFNLR1/IL10R beta dimer is the receptor for the cytokine ligands IFNL2 ａnd IFNL3 ａnd mediates their antiviral activity.

蛋白编号：Q08334/NP_000619.3 (M20-S220)

基因 ID：3588

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-10 受体  |  白介素-10 受体 β

Categories：Cytokines ａnd Growth Factors  |  Interleukin & Receptors  |  IL-10 Receptor  |  IL-10R beta

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