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Autoimmune Disease Compound Library

MCE 站：Autoimmune Disease Compound Library

Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, ａnd intracellular kinases. As key participants in innate immunity, macrophages ａnd dendritic cells (DCs) are crucial for Ag presentation ａnd pro-inflammatory cytokine production, such as TNF ａnd IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), ａnd the proliferation-inducing ligand (APRIL, also known as TNFSF13A). MCE designs a unique collection of 419 autoimmune disease-related compounds, covering multiple targets ａnd subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

Description & Advantages:

   A unique collection of 419 small molecules related to autoimmune diseases for high throughput screening (HTS) ａnd high content screening (HCS).

   Targets such as TNF Receptor, IFNAR, JAK, Btk, TLR, ａnd more.

   A useful tool for drug discovery.

   Target diverse, medicinally active ａnd cell permeable.

   Bioactivity ａnd safety confirmed by preclinical research ａnd clinical trials. Some have been approved by FDA.

   More detailed compound information with structure, IC50, ａnd other chemical & biological data.

   High purity ａnd quality validated by NMR ａnd LC/MS.

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
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