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Inflammasomes related Compound Library

MCE 站：Inflammasomes related Compound Library

Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses ａnd pyrolytic cell death, thereby exerting the host＇s defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines ａnd inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, ａnd pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration ａnd metabolic disorders, ａnd the development of cancer. Therefore, it is necessary to strictly regulate the activation ａnd function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.MCE designs a unique collection of 56 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer ａnd other diseases.

Description & Advantages:

   A unique collection of 56 inflammasomes related compounds for high throughput screening (HTS) ａnd high content screening (HCS).

   A useful tool for Inflammation, cancer ａnd other diseases research.

   Structurally diverse, medicinally active ａnd cell permeable.

   Bioactivity ａnd safety confirmed by preclinical research ａnd clinical trials. Some compounds have been approved by FDA.

   More detailed compound information with structure, IC50, ａnd other chemical & biological data.

   High purity ａnd quality validated by NMR ａnd LC/MS.

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