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p-Hydroxycinnamic acid

CAS No. : 7400-08-0

MCE 站：p-Hydroxycinnamic acid

产品活性：p-Hydroxycinnamic acid 是一种常见的食用酚，能够抑制血小板 (platelet) 的活性，其对血栓素 B₂ 和前列腺素 E₂ 的 IC₅₀ 值分别为 371 μM，126 μM。

研究领域：Metabolic Enzyme/Protease  |  GPCR/G Protein

作用靶点：Endogenous Metabolite  |  Prostaglandin Receptor

结构分类：酚类  |  单酚类  |  酮、醛、酸

In Vitro: p-Hydroxycinnamic acid (p-Coumaric acid), is a ubiquitous plant metabolite with antioxidant ａnd anti-inflammatory properties. p-Hydroxycinnamic acid (500 μM ａnd 1 mM) reduces ADP-induced platelet aggregation (552 (SE 401) % ａnd 356 (SE 235) % relative to basal level, respectively). p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary haemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B₂ production ａnd lipopolysaccharide-induced prostaglandin E₂ generation (IC₅₀ 371 ａnd 126 μM, respectively).

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