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4-Hydroxybenzoic acid

CAS No. : 99-96-7

MCE 站：4-Hydroxybenzoic acid

产品活性：4-Hydroxybenzoic acid 是苯甲酸的酚衍生物，可以抑制绝大多数的革兰氏阳性菌和部分革兰氏阴性菌，其 IC₅₀ 值为160 μg/mL。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Endogenous Metabolite  |  Bacterial

结构分类：酚类  |  单酚类  |  酮、醛、酸  |  结构分类

In Vitro: Most of the gram-positive ａnd some gram-negative bacteria are sensitive to trans 4-Hydroxycinnamic acid (4-HBA) ａnd 4-Hydroxybenzoic acid at IC₅₀ concentrations of 100-170 ａnd 160 μg/mL, respectively. The antimicrobial activities of 4-Hydroxycinnamic acid ａnd t4-HCA against 11 food pathogenic bacteria, 6 plant pathogenic bacteria, 2 yeasts ａnd 15 plant pathogenic fungi are tested by the paper disc method. These compounds inhibit the growth of most of the bacteria ａnd yeasts at concentrations of 200-400 μg. However, the inhibition is more effective against most of the gram-positive bacteria. When tested by the paper disc method, 4-Hydroxycinnamic acid has stronger antimicrobial activity than t4-HCA against S. aureus, L. mesenteroides, S. cerevisiae ａnd C. albicans at a concentration of 50 μg. However, no inhibitory effect against fungi was observed at concentrations even up to 1000 μg.

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