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Pyrogallol

CAS No. : 87-66-1

MCE 站：Pyrogallol

产品活性：Pyrogallol 是一种多酚化合物，具有抗真菌和抗牛皮癣的特性。Pyrogallol 是一种还原剂，能够产生自由基，特别是超氧阴离子。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection  |  Apoptosis

作用靶点：Endogenous Metabolite  |  Fungal  |  Apoptosis

结构分类：酚类

In Vitro: Pyrogallol (PG) is a reductant that is able to generate free radicals, in particular superoxide anions (O₂^-), so has frequently been used as a photographic developing agent ａnd in the hair dying industry. Pyrogallol inhibits Calu-6 ａnd A549 lung cancer cell growth via apoptosis ａnd depletion of glutathione (GSH). Pyrogallol (PG) induces apoptosis in lung cancer cells via the overproduction of O₂^- ａnd affects mitogen activated protein kinases (MAPKs) in these cells. The effect of Pyrogallol on human pulmonary fibroblast (HPF) cell viability ａnd necrotic cell death is examined. For these experiments, 0, 50 or 100 M Pyrogallol is used to differentiate the levels of cell viability inhibition or death with or without a given MAPK inhibitor. Treatment with 50 ａnd 100 M Pyrogallol decreases HPF viability by ~40 ａnd 65% at 24 h, respectively. Treatment with an MEK inhibitor slightly enhances the inhibition of cell viability in 50 M Pyrogallol-treated HPF cells, whereas treatment with a p38 inhibitor mildly attenuates the inhibition of viability. In 100 M Pyrogallol-treated HPF cells, all the MAPK inhibitors increase the inhibition of viability to a certain extent, with treatment with the p38 inhibitor alone augmenting HPF control cell viability. Necrotic cell death is determined by measuring lactate dehydrogenase (LDH) release from cells. While treatment with 50 M Pyrogallol does not affect LDH release from HPF cells, 100 M Pyrogallol significantly increases LDH release.

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