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CU-CPT-9a

CAS No. : 2165340-32-7

MCE 站：CU-CPT-9a

产品活性：CU-CPT-9a 是 TLR8 的特异性拮抗剂，其 IC₅₀ 值为 0.5 nM。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)

In Vitro: CU-CPT-9a is a specific TLR8 antagonist, with an IC₅₀ of 0.5±0.1 nM. The elevation of the downstream protein levels induced by R848 can be reversed by CU-CPT-9a in a dose-dependent manner. By contrast, the expression of TRIF ａnd IRF3 (cytoplasmic ａnd nuclear) are only responsive to TLR4 ａnd TLR3, independent of TLR837. The expression levels of TRIF ａnd IRF3 do not show significant change in THP-1 cells upon treatment of R848, nor do they change with the treatment of CU-CPT-9a. CU-CPT8m ａnd CU-CPT-9a both significantly suppress the TNF-α level in a dose-dependent manner, which is in agreement with previous reports of TLR8 involvement in these autoimmune diseases.

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