MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Ipragliflozin (L-Proline)

CAS No. : 951382-34-6

MCE 站：Ipragliflozin (L-Proline)

产品活性：Ipragliflozin (L-Proline) 是 SGLT2 高活性的，选择性抑制剂，IC₅₀ 为 2.8 nM，对 SGLT1/3/4/5/6 几乎无活性。

研究领域：Membrane Transporter/Ion Channel

作用靶点：SGLT

In Vitro: Ipragliflozin (L-Proline) potently ａnd selectively inhibits human, rat, ａnd mouse SGLT2 at nanomolar ranges ａnd exhibits stability against intestinal glucosidases.

In Vivo: Ipragliflozin (L-Proline) shows good pharmacokinetic properties following oral dosing, ａnd dose-dependently increases urinary glucose excretion, which lasts for over 12 h in normal mice . Oral administration of ipragliflozin increases urinary glucose excretion in a dose-dependent manner, an effect which is significant at doses of 0.3 mg/kg or higher ａnd lasts over 12 h. Single administration of ipragliflozin dose-dependently increases urinary glucose excretion, reduces blood glucose ａnd plasma insulin levels, ａnd improves glucose intolerance .

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Anti-diabetic Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Cancer Metabolism Compound Library  |  Anti-Obesity Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Mizagliflozin  |  Licogliflozin  |  Velagliflozin proline  |  HSK0935  |  Tofogliflozin  |  Enavogliflozin  |  Remogliflozin etabonate  |  T-1095  |  Empagliflozin-d₄  |  SGL5213  |  Dapagliflozin  |  Sotagliflozin  |  Ertugliflozin-d₅  |  Kushenol K  |  Phloretin  |  Luseogliflozin  |  TA-1887  |  SGLT1/2-IN-1  |  Tianagliflozin  |  Canagliflozin  |  Dapagliflozin impurity  |  LX2761

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。