MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Thiarabine

CAS No. : 26599-17-7

MCE 站：Thiarabine

产品活性：Thiarabine (OSI-7836) 具有抗肿瘤活性，能抑制 DNA 的合成。

研究领域：Cell Cycle/DNA Damage

作用靶点：DNA/RNA Synthesis

In Vivo: Thiarabine has demonstrated exceptional antitumor activity against numerous human tumor xenografts in mice, being superior to gemcitabine, clofarabine, or cytarabine. Unlike cytarabine, Thiarabine demonstrates excellent activity against solid tumor xenografts, suggesting that this agent has the kind of robust activity in animal models that leads to clinical utility. Thiarabine is effective orally (bioavailability of approximately 16%) ａnd with once per day dosing: Two characteristics that distinguish it from cytarabine. Although both the structure ａnd basic mechanism of action of Thiarabine are similar to that of cytarabine, there are many quantitative differences in the biochemical pharmacology of these two agents that can explain the superior antitumor activity of Thiarabine. Two important attributes are the long retention time of the 5＇-triphosphate of thiarabine in tumor cells ａnd its potent inhibition of DNA synthesis. The biochemical pharmacology of Thiarabine is also different from that of gemcitabine.

相关产品：IBU-DC Phosphoramidite  |  2,4-D sodium salt  |  N6-Benzoyl-2＇-deoxy-5＇-O-DMT-a-adenosine 3＇-CE phosphoramidite  |  Thailanstatin D  |  Carboplatin-d₄  |  Caracemide  |  N-DMTr-Morpholino-U-5＇-O-phosphoramidite  |  Farudodstat  |  Ara-ATP  |  DNA31  |  2＇-OMe-Ac-C Phosphoramidite  |  hDHODH-IN-12  |  Dasabuvir  |  DNA Gyrase-IN-4  |  Uridine triphosphate-¹³C₉,¹⁵N₂ sodium  |  5-Methylcytosine  |  Cidofovir dihydrate  |  Capecitabine-d₁₁  |  5-Fluoro-2′-deoxy-UTP  |  DMT-2＇-F-dA(bz) phosphoramidite  |  Tezacitabine  |  Mequindox  |  TH287 hydrochloride  |  DNA Gyrase-IN-1  |  DMT-2＇-F-Cytidine Phosphoramidite  |  2＇-O-MOE-5-Me-rU  |  Levofloxacin sodium  |  GC7 Sulfate  |  Psammaplin A

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。