型号:
产品价格:电议      采购度:155      原产地:美洲
发布时间:2023/12/4 16:30:45 所属地区:国外 国外
简要描述:
官网链接:https://
KG-501 是 CREB 的抑制剂,其 IC50 值为 μM。
产品详情
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 18228-17-6
MCE 站:KG-501
产品活性:KG-501 是 CREB 的抑制剂,其 IC50 值为 6.89 μM。
研究领域:Epigenetics
In Vitro: KG-501, which directly targets the KIX domain of CBP, results in a disrupted CREB-CBP complex, inhibits CREB-target gene induction, and inhibits IL-1β-mediated angiogenic activity in NSCLC. KG-501 disrupts phospho (Ser-133) CREB binding to KIX with a Ki of ~90 μM, using concentrations of CREB that are within the linear range of the binding assay. Treatment of HEK293T cells with KG-501 also blocks induction of endogenous CREB target genes (NR4A2, αCG, c-fos, and RGS2) by forskolin, indicating that KG-501 likely exerts a general effect on CREB activity. KG-501 can also inhibit NF-κB transcription activity because NF-κB also uses CBP as a cofactor to regulate gene expression. The migration of HUVECs induced by CM from A549 cells treated with IL-1β plus 10 μM of KG-501 is significantly lower than that induced by CM from A549 cells treated with IL-1β alone. At 10 μM, KG-501 suppresses the expression of all of the IL-1βinduced CXC chemokine genes except CXCL8. For the protein level, KG-501 significantly suppresses IL-1βinduced CXCL5 protein secretion. Similar effects of KG-501 are also observed in the H1734 cell line.
相关产品:Bioactive Compound Library Plus | Epigenetics Compound Library | Immunology/Inflammation Compound Library | Histone Modification Research Compound Library | Reprogramming Compound Library | Pyroptosis Compound Library | Anti-Lung Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Anti-Prostate Cancer Compound Library | Pain-Related Compound Library | BRD4 Inhibitor-18 | ACBI2 | BI01826025 | Curcumin | GSK6853 | MI-1 | GSK 4027 | ZL0590 | BRD4 Inhibitor-26 | Apabetalone | PROTAC BRD2/BRD4 degrader-1 | MS645 | OF-1 | I-CBP112 | BRM/BRG1 ATP Inhibitor-2 | UMB-32 | Ziftomenib | CeMMEC2 | GSK761 | XX-650-23 | KB02-JQ1 | CD235 | I-BET151 | VZ185 | BET-IN-6 | PLK1/BRD4-IN-1 | MI-136 | SF2523 | BET-IN-15
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
• 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
更新时间:2024/1/2 10:32:24
留言咨询
温馨提示
1.遵守中华人民共和国有关法律、法规,尊重网上道德,承担一切因您的行为而直接或间接引起的法律责任。
2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。
3.未经本站同意,任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。
相关新闻
相关产品