产品中心

JSH-150

型号:

产品价格:电议      采购度:151      原产地:美洲

发布时间:2023/12/4 16:32:13      所属地区:国外 国外

简要描述:

官网链接:https://
JSH-150 是一种高效的选择性 CDK9 抑制剂, IC50 为 1 nM。

产品咨询 服务电话:
021-58955995
分享到:

标签:jsh   150   

产品详情

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。

JSH-150

CAS No. : 2247481-21-4

MCE 站:JSH-150

产品活性:JSH-150 是一种高效的选择性 CDK9 抑制剂, IC50 为 1 nM。

研究领域:Cell Cycle/DNA Damage

作用靶点:CDK

In Vitro: The antiproliferative effect of JSH-150 is examined ton a panel of established cancer cell lines. JSH-150 exhibits potent antiproliferative activities in solid tumor cell lines such as A375 (melanoma), A431 (squamous), BE(2)M17 (neuroblastoma), GIST-T1 (GIST) and COLO205 (colon cancer) with GI50 values from 0.002 to 0.044 M. In the leukemia cell lines including acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and B cell lymphoma cell lines, JSH-150 also displays strong growth inhibition efficacies with GI50s ranging from single to double digit nM. In addition, JSH-150 is much less sensitive in normal CHO cells (GI50: 1.1 M) compared with the cancer cell lines.

In Vivo: Treatment of JSH-150 at all dosages, i.e., 10, 20 and 30 mg/kg/day, can almost completely suppress the tumor progression in the first two weeks and does not affect the animal’s weight indicating that there is no general cytotoxicity at these doses. After stopping the treatment of JSH-150, the tumors of the animals treated with 10 mpk drug dosage start to grow again. However, this tumor recurrence is not observed in the 20 and 30 mpk dosage groups during the following week after administration of JSH-150 is stopped and p values are quantified on the 21st day, which are 0.042, 0.0035 and 0.0028, respectively. The PK properties of JSH-150 are evaluated in different species including mice, Sprague-Dawley rats and beagle dogs through intravenous injection and oral administration. JSH-150 is absorbed rapidly in dogs and mice (Tmax=1.33 h and 2.00 h respectively) but slowly in rats (Tmax=3.33 h). JSH-150 also displays different half-lives in three different species via oral administration (T1/2=1.55 h in mice, 3.37 h in rats and 20.37 h in dogs), which indicates that it is metabolized very slowly in dogs compared with mice and rats. In addition, JSH-150 exhibits acceptable bioavailability in mice, rats and dogs (F=45.01%, 45.10% and 39.15%, respectively). The PK properties indicated that JSH-150 is suitable for oral administration.

相关产品:Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Covalent Screening Library  |  Anti-Breast Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Targeted Diversity Library  |  Cancer Stem Cells Compound Library  |  Heterocyclic Compound Library  |  Membrane Protein-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Serine/Threonine Kinase Inhibitor Library  |  SY-5609  |  CLK1/2-IN-1  |  MFH290  |  SB-218078  |  Toyocamycin  |  (S)-LY3177833 hydrate  |  Dinaciclib  |  EGFR/HER2/CDK9-IN-2  |  CDK8-IN-11  |  SNS-032  |  M2N12  |  Palbociclib-d8  |  EGFR/CDK2-IN-1  |  BSJ-04-132  |  (E/Z)-Zotiraciclib  |  CCT-251921  |  BS-181  |  A09-003  |  (R)-PROTAC CDK9 ligand-1  |  Ribociclib-d8  |  CDK9-IN-9  |  Flavopiridol  |  SRI-29329  |  dCeMM4  |  GSK 3 Inhibitor IX  |  CDK9-IN-7  |  PROTAC CDK9 degrader-8  |  BSJ-03-204  |  Amantadine-d6  |  K00546

热门产品线:重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products:Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物;
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
•   产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
•   提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
•   设有专业的实验中心和严格的质控、验证体系;
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
•   产品的生物活性多经各国客户实验验证;
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
•   专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
•   与世界各大制药公司及知名科研机构建立了长期的合作。

类药多样性化合物库
顾客使用MCE产品发表的科研文献
一站式药筛新体验
MCE 您身边的生物活性分子大师 | 抑制剂、激动剂、化合物库
重组蛋白 | 高纯度、高稳定性
磁珠
MCE Hotline: 4008203792 | 中国现货 - 全球文献引用 - 高纯度高品质 - 全方位技术支持

更新时间:2024/1/2 10:32:24

留言咨询

  •  
  •  
  •  
  •  
  •  
  •  
  •  
验证码: 点击切换验证码

温馨提示

1.遵守中华人民共和国有关法律、法规,尊重网上道德,承担一切因您的行为而直接或间接引起的法律责任。
2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。
3.未经本站同意,任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。

相关新闻

相关产品

联系我们

电话:021-58955995
传真:021-53700325
邮箱:sales@medchemexpress.cn
地址:上海上海

版权所有©MedChemExpress, All Right Reseverd ICP备案号: 总访问量:10992326 管理登录 阿仪网 设计制作,未经允许翻录必究

8

阿仪网推荐收藏该企业网站

联系方式

18019480960
18019480960

工作时间

(24小时)