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IR 813 tosylate

CAS No. : 134127-48-3

MCE 站：IR 813 tosylate

产品活性：IR 813 tosylate 是一种近红外 (NIR) 荧光染料 (λ_ex=815 nm，λ_em=840 nm)，可用于对小鼠的局部淋巴结进行可视化。

研究领域：Others

作用靶点：Fluorescent Dye

In Vitro: IR 813 (17.3 μM, 2 h) tosylate induces a 31.4% hemolysis in red blood cells.
IR 813 (5.9 μM, 24 h) tosylate induces 50% cell death in MRC-5 cells.

In Vivo: IR 813 tosylate displays a maximum fluorescence intensity at 4 h postinjection together with a rapid extravasation, when being used for visualizing regional lymph nodes in mice.
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, ａnd should be modified according to your specific needs).
1. Animal: Ten-week-old female Balb/cOlaAnN mice are kept in a 12 h light/dark cycle to reduce tissue autofluorescence in the NIR region, ａnd had access to food ａnd water ad libitum.
2. Dose: A single dose 5.1 nmol of IR 813 dye (20 μL of 0.173 mg/mL, dissolved in a PEG-400/ethanol/water=3:2:5, v/v/v solution) is subcutaneous injected in the right anterior paw of mice.
3. Imaging: Using the Fluobeam700 NIR imaging system to perform in vivo optical imaging (739 nm excitation light (3.5 mW), 750 nm long-pass emission cutoff filter).Fluorescence intensity in the axillary lymph node (ALN) is recorded for 1 week (5 min, 1 h, 4 h, 24 h, 7 days).
4. Data analysis: Semiquantitative data is obtained from the fluorescence images using ImageJ 1.44 software.

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