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Deuruxolitinib

CAS No. : 1513883-39-0

MCE 站：Deuruxolitinib

产品活性：Deuruxolitinib，是一种氘代的 Ruxolitinib，可调节 JAK1/JAK2 的活性。Deuruxolitinib 可用于研究脱发疾病 (详细信息来自 WO2017192905A1，compound I)。

研究领域：Epigenetics  |  Protein Tyrosine Kinase/RTK  |  JAK/STAT Signaling  |  Stem Cell/Wnt

作用靶点：JAK

In Vitro: "Stable heavy isotopes of hydrogen, carbon, ａnd other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic ａnd metabolic profiles of drugs.
Potential advantages of deuterated compounds:
(1) Extend the half-life in vivo. Deuterated compounds may be able to prolong the pharmacokinetic characteristics of the compound, that is, prolong the half-life in vivo. This can improve compound safety, efficacy ａnd tolerability, ａnd increase ease of administration.
(2) Improve oral bioavailability. Deuterated compounds may reduce the degree of unwanted metabolism (first-pass metabolism) in the gut wall ａnd liver, allowing a greater proportion of the unmetabolized drug to reach its target site of action. High bioavailability determines its activity at low doses ａnd better tolerance.
(3) Improve metabolic characteristics. Deuterated compounds may reduce the formation of toxic or reactive metabolites ａnd improve drug metabolism.
(4) Improve drug safety. Deuterated compounds may reduce or eliminate adverse side effects of pharmaceutical compounds ａnd are safe.
(5) Preserve the therapeutic properties. Deuterated compounds are expected to retain similar biochemical potency ａnd selectivity to hydrogen analogs in previous studies.
"

相关产品：Ruxolitinib  |  Tofacitinib  |  Deucravacitinib  |  Baricitinib  |  AG490  |  Upadacitinib  |  Fedratinib  |  Ritlecitinib  |  Pacritinib  |  Momelotinib  |  WP1066  |  Filgotinib  |  Butyzamide  |  RO8191  |  AZD-1480  |  AT9283  |  Abrocitinib  |  Peficitinib  |  CHZ868  |  Cucurbitacin I  |  Itacitinib  |  Gandotinib  |  (E/Z)-Zotiraciclib  |  Pyridone 6  |  Crocin  |  JAK2 JH2 Tracer  |  Atractylenolide I

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