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PTP1B Antibody (YA1776)

MCE 站：PTP1B Antibody (YA1776)

PTP1B Antibody (YA1776) 是无偶联基团的、靶向 PTP1B 的 IgG 抗体 (克隆号：YA1776)，预测分子量为 50 kDa (实际观测：50 kDa)。PTP1B Antibody (YA1776) 可用于人背景下的 WB、IHC-F、IHC-P、ICC/IF 实验。

Synonyms: PTPN1; PTP1B; Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B

研究背景：The protein encoded by The related gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated ａnd identified based on its enzymatic activity ａnd amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, ａnd oncogenic transformation. The PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. The PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 ａnd TYK2 kinases, which implicated the role of The PTP in cell growth control, ａnd cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for The related gene.

基因 ID：5770

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