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Factor XIIIa Antibody (YA1631)

MCE 站：Factor XIIIa Antibody (YA1631)

Factor XIIIa Antibody (YA1631) 是无偶联基团的、靶向 Factor XIIIa 的 IgG 抗体 (克隆号：YA1631)，预测分子量为 83 kDa (实际观测：83 kDa)。Factor XIIIa Antibody (YA1631) 可用于人背景下的 WB、IHC-P 实验。

Synonyms: Coagulation factor XIIIa; F13A; F13a1; Fibrin stabilizing factor; A subunit; Fibrinoligase; TGase; Transglutaminase A chain

研究背景：The related gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits ａnd 2 B subunits. The A subunits have catalytic function, ａnd the B subunits do not have enzymatic activity ａnd may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin ａnd in the presence of calcium ion, the plasma factor XIII dissociates its B subunits ａnd yields the same active enzyme, factor XIIIa, as platelet factor XIII. The enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A ａnd B subunits; ａnd type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, ａnd habitual abortion.

基因 ID：2162

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