PE859

CAS No. : 1402727-29-0

MCE 站：PE859

产品活性：PE859是tau和Aβ积累的有效抑制剂，IC₅₀值分别为0.66 和1.2 μM。

研究领域：Cell Cycle/DNA Damage  |  Cytoskeleton

作用靶点：Microtubule/Tubulin

In Vitro: PE859 inhibits the heparin-induced aggregation of both 3RMBD ａnd full length tau in a concentration-dependent manner. In each assay, the IC₅₀ values calculated at the last measurement periods are 0.81 μM, ａnd 2.23 μM, respectively. PE859 inhibits tau aggregation through formation of beta-sheet structure.

In Vivo: PE859 could cross the blood-brain barrier ａnd that PE859 could be distributed into the tissues of the central nervous system. The maximum concentration of PE859 is 2.005 μg/mL in the blood at 3 h ａnd 1.428 μg/g in the brain at 6 h. PE859 delays onset ａnd progression of the motor dysfunction in JNPL3 mice. PE859 delays progression of the motor dysfunction through the inhibition of accumulation of sarkosyl-insoluble tau.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Anti-Aging Compound Library  |  Cytoskeleton Compound Library  |  Paclitaxel  |  Docetaxel  |  Nocodazole  |  Vincristine sulfate  |  Colchicine  |  VcMMAE  |  Mertansine  |  Eribulin mesylate  |  Vinorelbine ditartrate  |  2-Methoxyestradiol  |  Vinblastine sulfate  |  D8-MMAE  |  DM4  |  Cabazitaxel  |  McMMAF  |  Epothilone D  |  MMAF hydrochloride  |  Taltobulin  |  Flubendazole  |  Epothilone B  |  Estramustine phosphate sodium  |  Parbendazole  |  Triclabendazole  |  Combretastatin A4  |  Fosbretabulin disodium  |  Ixabepilone  |  Ansamitocin P-3  |  Podofilox  |  BTB-1

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。