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Ginsenoside Rg5

CAS No. : 186763-78-0

MCE 站：Ginsenoside Rg5

产品活性：Ginsenoside Rg5 是红参的主要成分。Ginsenoside Rg5 阻断 IGF-1 与其受体的结合，IC₅₀ 约为90 nM。Ginsenoside Rg5 还通过抑制 NF-κB p65 的 DNA 结合活性来抑制 COX-2 的 mRNA 表达。

研究领域：Protein Tyrosine Kinase/RTK  |  NF-κB  |  Immunology/Inflammation

作用靶点：IGF-1R  |  NF-κB  |  COX

In Vitro: Ginsenoside Rg5 plays a novel role as an IGF-1R agonist. Ginsenoside Rg5 binds to IGF-1R with an IC₅₀ value of ~90 ａnd its angiogenic activity is inhibited by IGF-1R knockdown. To investigate the possible interaction of Ginsenoside Rg5 with IGF-1R, a docking analysis is performed. Docking results show that Ginsenoside Rg5 binds strongly at two sites, A ａnd B, with K_d values of 20 ａnd 27 nM, respectively, to the cysteine-rich domain of IGF-1R. Pretreatment with Rg5 blocks the binding of radiolabeled IGF-1 to HUVECs with an IC₅₀ value of ~90 μM, which is greater than an IC₅₀ value of ~1.4 nM for unlabeled IGF-1. The results from MTT assay show that MCF-7 cell proliferation is inhibited by Ginsenoside Rg5 treatment for 24, 48 ａnd 72 h in a dose-dependent manner. Ginsenoside Rg5 at different concentrations (0, 25, 50 ａnd 100 μM), induce cell cycle arrest in G0/G1 phase through regulation of cell cycle-related proteins in MCF-7 cells.

In Vivo: Ginsenoside Rg5 inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65 in lipopolysaccharides (LPS)-stimulated BV2 microglial cells. Rg5 pretreated group mice show declined expression of NF-κB p65 ａnd COX-2. In the group treated with low dose of Ginsenoside Rg5 (10 mg/kg), there is remarkable tubular damage ａnd infiltration of inflammatory cells. However, at the higher dose of Ginsenoside Rg5 (20 mg/kg), tubules markedly appeare histologically normal ａnd no inflammation ａnd cast formation is observed in kidney tissues.

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