Tetrandrine产品描述：Tetrandrine is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca²⁺ current (ICa) and Ca²⁺-activated K⁺ current.IC50 & Target: Ca²⁺ current^[1]
K⁺ current^[1]In Vitro: The effects of Tetrandrine, a bis-benzyl-isoquinoline alkaloid, on voltage-gated Ca²⁺ currents (ICa) and on Ca²⁺-activated K⁺ current (IK(Ca)) and channels in isolated nerve terminals of the rat neurohypophysis are investigated using patch-clamp techniques. The non-inactivating component of ICa is inhibited by external Tetrandrine in a voltage- and dose-dependent manner, with an IC₅₀=10.1μM. Tetrandrine decreases the channel-open probability, within bursts, with an IC₅₀=0.21 μM^[1]. To evaluate the effects of Tetrandrine on HCC cells, Huh7, HCCLM9 and Hep3B cells are treated with 0 (DMSO), 0.5, 1, 2 or 4 μM of Tetrandrine for 24 h. The cell proliferation assay indicates that Tetrandrine exhibits almost no effect on the inhibition of HCC cell proliferation at 0.5-2 μM. However, Tetrandrine inhibits HCC cell migration in a dose-dependent manner. Furthermore, a wound-healing and transwell assay shows that 2 μM Tetrandrine significantly inhibits HCC cell migration and invasion^[2].In Vivo: To evaluate the effect of Tetrandrine on the inhibition of tumor metastasis in vivo, HCCLM9 subcutaneous tumor xenograft models is established with athymic nude mice. When the tumor volume reach approximately 50 mm³, nude mice are orally administered vehicle or Tetrandrine (30 mg/kg) every other day for 37 days. Tetrandrine treatment inhibits tumor growth by reducing the tumor volume and weight^[2].
产品链接：www.medchemexpress.com/Tetrandrine.html

研究领域：Membrane Transporter/Ion Channel

靶点：Calcium ChannelPotassium Channel

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更新时间：2024/1/2 10:10:55