(±)-10-Hydroxycamptothecin产品描述：(±)-10-Hydroxycamptothecin, an indole alkaloid isolated from Camptotheca acuminate, inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.IC50 & Target: Topoisomerase I^[1]In Vitro: (±)-10-Hydroxycamptothecin (10-OH-camptothecin) is an inhibitor of topo I^[1]. (±)-10-Hydroxycamptothecin (10-HCPT, 5-20 nM) markedly inhibits the proliferation of Colo 205 cells in a dose-dependent manner. (±)-10-Hydroxycamptothecin (5-20 nM) arrests Colo 205 cells in the G2 phase of the cell cycle and triggers apoptosis through a caspase-3-dependent pathway^[2]. (±)-10-Hydroxycamptothecin (HPT, 0.01-10 μg/mL) causes cell shrinage, nuclear fragmentation and condensed chromosomes and induces apoptosis of human urinary bladder cancer cell line (T24)^[3].In Vivo: (±)-10-Hydroxycamptothecin (10-HCPT, 2.5-7.5 mg/kg/2 days, p.o.) significantly suppresss tumor growth in mouse xenografts. (±)-10-Hydroxycamptothecin (1-7.5 mg/kg, p.o., once per 2 or 4 days) causes no obvious acute toxicity in nude mice^[2].
产品链接：www.medchemexpress.com/__plusmn__-10-Hydroxycamptothecin.html

研究领域：Cell Cycle/DNA Damage

靶点：Topoisomerase

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更新时间：2024/1/2 10:10:55