(+)-Catechin hydrate产品描述：(+)-Catechin hydrate, a strong antioxidant that scavenges radicals, is a phenolic compound that is extracted from plants and is present in natural food and drinks.In Vitro: A dose-dependent reduction in color is observed after 24 hours of treatment with (+)-Catechin hydrate (CH), and 54.76% of the cells are dead at the highest concentration of (+)-Catechin hydrate tested (160 μg/mL) whereas the IC₅₀ of (+)-Catechin hydrate is achieved at 127.62 μg/mL (+)-Catechin hydrate. A dose- and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with (+)-Catechin hydrate. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL (+)-Catechin hydrate, respectively, undergo apoptosis. The expression levels of Caspase-3, -8, and -9 and p53 in MCF-7 cells treated with 150 μg/mL (+)-Catechin hydrate for 24 h increase by 5.81, 1.42, 3.29, and 2.68 fold, respectively, as compare to the levels in untreated control cells^[1].In Vivo: Animals treated with (+)-Catechin hydrate at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. (+)-Catechin hydrate prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with (+)-Catechin hydrate prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively)^[2].
产品链接：www.medchemexpress.com/__addition__-Catechin_hydrate.html

研究领域：Flavonoids

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更新时间：2024/1/2 10:10:55