5-HT3-In-1 来自 EP0748807A1，化合物实例8。它有抑制 5-HT3 的活性。

Dencichin产品描述：Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, ａnd can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.IC50 & Target: PHD-2^[1]In Vitro: Dencichin (β-ODAP, 10 μM, 50 μM, 100 μM ａnd 200 μM) increases HRE expression by 1.3±0.09, 2.5±0.07, 4.2±0.15 ａnd 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2^[1]. Dencichin (10 μM, 100 μM, 1 mM) significantly inhibits cell proliferation ａnd extracellular matrix (ECM) proteins accumulation of HBZY-1 cells, ａnd reduces the secretion of collagen I (Col I), collagen IV (Col IV), ａnd fibronectin (FN)^[2].In Vivo: Dencichin improves metabolism disorder in diabetic nephropathy (DN) secondary to type II diabetes mellitus (DM) model. Dencichin (80, 160 mg/kg/day, p.o.) significantly prevents the up-regulation of TCH, TG, LDL, ａnd HbAlc ａnd the down-regulation of HDL in DN rats induced by STZ injection. Dencichin also attenuates renal injury induced in the DN secondary to type II DM model. Dencichin alleviates pancreas damage in the STZ-induced DN model. Dencichin regulates protein expression in the TGF-β/Smad signalling pathway in STZ-induced DN models^[2].
产品链接：www.medchemexpress.com/Dencichin.html

研究领域：Metabolic Enzyme/Protease

靶点：HIF/HIF Prolyl-Hydroxylase

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更新时间：2024/1/2 10:10:55