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产品价格:电议      采购度:1683      原产地:美洲
发布时间:2021/7/23 21:13:36 所属地区:上海 上海市
简要描述:
Pertuzumab 是一种人源化单克隆抗体,是一种HER2二聚抑制剂。可用于转移性HER2 阳性乳腺癌的研究。
标签:Perjeta
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CAS No. : 380610-27-5
MCE 站:Pertuzumab
产品活性:Pertuzumab 是一种人源化单克隆抗体,是一种HER2二聚抑制剂。可用于转移性HER2 阳性乳腺癌的研究。
研究领域:JAK/STAT Signaling | Protein Tyrosine Kinase/RTK
作用靶点:EGFR
In Vitro: Trastuzumab and Pertuzumab are highly synergistic inhibitors of BT474 breast cancer cell survival. The combination of trastuzumab and Pertuzumab mediates a loss of up to 60% of cells at doses in which individual drugs do not alter cell survival. The combination of trastuzumab and Pertuzumab reduces the percentage of proliferating (S-phase) cells by more than 2-fold. A combination of trastuzumab and Pertuzumab inhibits cell proliferation and survival to a greater degree than does either agent alone.
In Vivo: In Calu-3 NSCLC xenografts, monotherapy with pertuzumab or trastuzumab is able to significantly inhibit tumor growth, with treatment-to-control ratios (TCR) of 0.23 and 0.27, respectively. The combination of trastuzumab and pertuzumab produces a dramatically enhanced antitumor activity compared with single-agent treatments (TCR 0.05, resulting in tumor regression and, in 3 of 10 animals, complete tumor remission). Treatment of KPL-4 breast cancer xenografts with either trastuzumab or pertuzumab inhibits tumor growth with TCRs of 0.67 and 0.65, respectively. Pertuzumab maintains antitumor activity after progression on trastuzumab.
相关产品:Gefitinib | Trastuzumab | Erlotinib | Cetuximab | AG490 | Genistein | AG-1478 | BI-4020 | NSC 228155 | Pelitinib | Mubritinib | TX1-85-1 | Canertinib | Butein | PD168393 | Daphnetin | EGFR-IN-7 | AEE788 | Chrysophanol | PD153035 | Tyrphostin 23 | Lavendustin A | Trastuzumab emtansine | BMS-599626 Hydrochloride | PD158780 | AV-412
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更新时间:2024/1/2 10:14:16
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