MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

SB-431542

CAS No. : 301836-41-9

MCE 站：SB-431542

产品活性：SB-431542 是一种有效，选择性的 ALK5/TGF-β type I Receptor 抑制剂，IC₅₀ 值为 94 nM。

研究领域：TGF-beta/Smad

作用靶点：TGF-β Receptor

In Vitro: SB-431542 (1 μM) significantly reduces the TGF-β-induced nuclear accumulation of Smad proteins in A498 cells. SB-431542 inhibits TGF-β1-induced collagen Iα1 and PAI-1 mRNA with IC₅₀ values of 60 and 50 nM, respectively. In addition, SB-431542 inhibits TGF-β1-induced fibronectin mRNA and protein with IC₅₀ values of 62 and 22 nM, respectively. SB-431542 (10 μM) is a selective inhibitor of TGF-β signaling but has no effect on BMP signaling in NIH 3T3 cells. TRKI, SB-431542, inhibits TGF-beta-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 attenuates the tumor-promoting effects of TGF-beta, including TGF-beta-induced EMT, cell motility, migration and invasion, and vascular endothelial growth factor secretion in human cancer cell lines. SB-431542 induces anchorage independent growth of cells that are growth-inhibited by TGF-beta, whereas it reduces colony formation by cells that are growth-promoted by TGF-beta. SB-431542 (0.3 μM) inhibits cell proliferation induced by TGF-β in MG63 cells.

In Vivo: SB-431542 (10 mg/kg, i.p.) decreases lung metastasis but does not significantly alter growth of the primary tumor 4T1 xenograft.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  TGF-beta/Smad Compound Library  |  Anti-Cancer Compound Library  |  Reprogramming Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Dorsomorphin  |  A 83-01  |  LDN193189  |  RepSox  |  SB 525334  |  DMH-1  |  SB-505124  |  BMP signaling agonist sb4  |  GW788388  |  ITD-1  |  LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)  |  SD-208  |  LDN-212854  |  K02288  |  LDN-214117  |  R-268712  |  SM 16  |  A 77-01  |  ALK2-IN-2  |  PD-161570  |  pm26TGF-β1 peptide TFA  |  Isosaponarin  |  BIO-013077-01

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。