MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

LY3200882

CAS No. : 1898283-02-7

MCE 站：LY3200882

产品活性：LY3200882 是一种有效的，高度选择性的，具有 ATP 竞争性和口服活性的 TGF-β 受体 1 型 (ALK5) 抑制剂，IC₅₀ 为 38.2 nM。LY3200882 可抑制多种促肿瘤活性，还用作免疫调节剂。

研究领域：TGF-beta/Smad

作用靶点：TGF-β Receptor

In Vitro: LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells in a dose dependent fashion.
LY3200882 shows potent anti-tumor activity in the orthotopic 4T1-LP model of triple negative breast cancer and this activity correlated with enhanced tumor infiltrating lymphocytes in the tumor microenvironment.
In in vitro immune suppression assays, LY3200882 has shown the ability to rescue TGFβ1 suppressed or T regulatory cell suppressed naive T cell activity and restore proliferation.
LY3200882 inhibits NIH₃T₃ cell viability with an IC₅₀ of 82.9 nM.

In Vivo: LY3200882 (60 mg/kg; oral gavage; twice a day; for 21 days; BALB/C female mice) treatment significantly delays tumor growth in CT26 model.
LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vivo in subcutaneous tumors in a dose dependent fashion.
LY3200882 has shown anti-metastatic activity in vivo in an experimental metastasis tumor model (intravenous EMT6-LM2 model of triple negative breast cancer).

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  TGF-beta/Smad Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Drug Repurposing Compound Library  |  Reprogramming Compound Library  |  Orally Active Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  SB-431542  |  Dorsomorphin  |  A 83-01  |  LDN193189  |  RepSox  |  SB 525334  |  DMH-1  |  SB-505124  |  BMP signaling agonist sb4  |  GW788388  |  ITD-1  |  LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)  |  SD-208  |  LDN-212854  |  K02288  |  LDN-214117  |  R-268712  |  SM 16  |  A 77-01  |  ALK2-IN-2  |  PD-161570  |  pm26TGF-β1 peptide TFA  |  Isosaponarin  |  BIO-013077-01

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。