MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Sodium 2-oxopropanoate

CAS No. : 113-24-6

MCE 站：Sodium 2-oxopropanoate

产品活性：Sodium 2-oxopropanoate (Sodium pyruvate)，葡萄糖的三碳代谢物，是一种在糖酵解途径中产生的化合物。Sodium 2-oxopropanoate是一种可以清除 ROS 的自由基清除剂。

研究领域：NF-κB  |  Immunology/Inflammation  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species  |  Endogenous Metabolite

In Vitro: In the process of scavenging hydrogen peroxide, Sodium 2-oxopropanoate (Sodium pyruvate) is decarboxylated to lactate and hence diverted away from aerobic metabolism and further ROS generation. Under conditions in which pyruvate stimulated JNK1 activity, both mitochondrial and cytosolic ROS levels rose. An increase in JNK1 activity in a variety of different cell types over a range of pyruvate concentrations are observed.
Sodium 2-oxopropanoate (Sodium pyruvate) is an effective scavenger of H₂O₂ as well as of O₂?-, thereby protecting the lens against oxidative stress and consequent cataract formation, under in vitro as well as in vivo conditions, Sodium 2-oxopropanoate has also been shown to protect the lens proteins against glycation by competitively inhibiting the initial reaction between the sugar carbonyl and the protein -NH₂.

In Vivo: Neonatal rats are given a bolus of Sodium 2-oxopropanoate (Sodium pyruvate; 0.1-10 g/kg), and 1 h later, levels of JNK1 activity were determined in liver extracts. Sodium 2-oxopropanoate (Sodium pyruvate) addition resulted in a significant increase in JNK1 activity. Analysis of serum levels of Sodium 2-oxopropanoate in neonatal rats revealed that baseline levels of pyruvate are 0.30 mM. At the time of sacrifice, following the largest dose of Sodium 2-oxopropanoate, serum levels rose approximately sixfold to 1.84 mM.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Fragment Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Gut Microbial Metabolite Library  |  Microbial Metabolite Library  |  Anti-Parkinson's Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Mitochondria-Targeted Compound Library  |  Food Additive Library   |  Food-Sourced Compound Library   |  Rapamycin  |  3-Methyladenine  |  Acetylcysteine  |  5-Fluorouracil  |  H2DCFDA  |  ATP  |  Retinoic acid  |  Hydrocortisone  |  Quercetin  |  Estradiol  |  Docetaxel  |  Mitoquinone mesylate  |  Melatonin  |  Nicotinamide  |  Isoprenaline hydrochloride  |  Cytarabine  |  Prostaglandin E2  |  Acetaminophen  |  Capsaicin  |  L-Ascorbic acid  |  (-)-Epigallocatechin Gallate  |  Nicotinamide riboside chloride  |  β-Nicotinamide mononucleotide  |  Mito-TEMPO  |  DHEA  |  Calcitriol  |  Luteolin  |  Palmitic acid  |  Diphenyleneiodonium chloride  |  Thymidine

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。