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Lithium citrate tetrahydrate

CAS No. : 6080-58-6

MCE 站：Lithium citrate tetrahydrate

产品活性：Lithium citrate (Litarex) tetrahydrate 是藤黄果的主要活性成分。Lithium citrate tetrahydrate 可竞争性抑制柠檬酸裂解酶 (ATP citrate lyase) ，并具有减肥效果。Lithium citrate tetrahydrate 有效抑制结石形成并抑制 HIF，具有抗氧化，抗炎和抗肿瘤作用。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：ATP Citrate Lyase  |  Bacterial  |  HIF/HIF Prolyl-Hydroxylase

In Vitro: Lithium citrate tetrahydrate shows an HIF inhibitory effect compared with the control group in ARPE19 cells ａnd 661W cells. Lithium citrate tetrahydrate can downregulate Hif1a ａnd the downstream genes in ARPE19 cells ａnd 661W cells. Lithium citrate tetrahydrate suppresses HIF-1α protein expression increased by CoCl₂ administration in ARPE19 cells ａnd 661W cells.
In chicken hepatocytes, Lithium citrate tetrahydrate decreases the accumulation of lipid droplets ａnd accelerated energy metabolism. Lithium citrate tetrahydrate protects the cells from ER stress by increasing the antioxidant status ａnd mitochondrial functions.

In Vivo: Lithium citrate (100-200 mg/kg) tetrahydrate treatment could reduce markers of renal impairment (Blood Urea Nitrogen ａnd serum creatinine). There is significantly less calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Lithium citrate tetrahydrate. Lithium citrate tetrahydrate attenuates the oxidative stress induced by calcium oxalate crystallization. Lithium citrate tetrahydrate has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, ａnd IL-6. In addition, Lithium citrate tetrahydrate alleviates tubular injury ａnd apoptosis caused by calcium oxalate crystals.
The administration of Lithium citrate tetrahydrate can suppress body weight gain ａnd fat accumulation in animals.

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