MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Bicuculline methochloride

CAS No. : 38641-83-7

MCE 站：Bicuculline methochloride

产品活性：Bicuculline ((+)-Bicuculline; d-Bicuculline) 甲基氯化物是一种惊厥生物碱，是选择性GABA_A 受体 (GABAA receptor) 的拮抗剂，IC₅₀ 为 3 μM。Bicuculline 甲基氯化物在哺乳动物中可以诱导阵挛性强直性惊厥，还可用于阻断 Ca²⁺ 激活的钾通道。Bicuculline 甲基氯化物可用于癫痫等相关精神疾病的研究。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：GABA Receptor

In Vitro: Bicuculline methochloride (1 μM ａnd 3 μM) attains the maximal response of GABA. Bicuculline methochloride appears to shift the doseresponse curves of GABA in parallel to the right without decreasing GABA maximal response, suggesting that it is a competitive antagonist at human α₁β₂γ_2L GABA_A receptors expressed in Xenopus oocytes.
Bicuculline methochloride (1-100 μM; 2 min; applied as outside-out patches) potently blocks both Apamin (HY-P0256)-sensitive small-conductance calcium-activated potassium channels (SK2) currents ａnd Apamin-insensitive SK1 currents in Xenopus oocytes.

In Vivo: Bicuculline methochloride (1.25-3 mg/kg; s.c.) can cause clonus-tonic convulsions in a dose-dependent manner in mice ａnd these convulsions are enhanced by injection of the μ-opioid agonist morphine.
Bicuculline methochloride (1.5-3.2 mg/kg; s.c.) induces male Swiss S mice generalized seizures with a CD₅₀ (convulsant dose) of 2.2 mg/kg for clonus ａnd CD₅₀ of 2.4 mg/kg for tonus. Seizures induced by Bicuculline methochloride at the dose of 3.2 mg/kg can be blocked by pretreatment (i.p.) with the NMDA antagonists MK-801, CPP ａnd CGS 19755.

相关产品：SKF89976A hydrochloride  |  rac-BHFF  |  Tiagabine hydrochloride hydrate  |  Lesogaberan napadisylate  |  (2S)-6-Prenylnaringenin  |  GABAB receptor antagonist 1  |  FG8119  |  3α,21-Dihydroxy-5α-pregnan-20-one  |  CGP35348  |  (-)-α-Pinene  |  γ-Acetylenic GABA  |  Picrotoxinin  |  Chrodrimanin B  |  GABAA receptor agent 2 TFA  |  3α,21-Dihydroxy-5α-pregnan-20-one-d3  |  Valiloxibic acid  |  Baclofen hydrochloride  |  Ginsenoside Rc  |  Flutazolam  |  TP003  |  Fluxametamide  |  GS39783  |  Oxiracetam  |  Isoguvacine hydrochloride  |  Valerenic acid  |  Etiocholanolone-d5  |  GABAA receptor agent 5  |  mGAT3/4-IN-2

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   40,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。