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L-Thyroxine sodium xhydrate

CAS No. : 25416-65-3

MCE 站：L-Thyroxine sodium xhydrate

产品活性：L-Thyroxine sodium xhydrate (Levothyroxine; T4) 是一种合成的甲状腺激素，用于治疗甲状腺功能减退症。DIO 酶将 L-Thyroxine (T4) 转化成具有生物活性的三碘甲状腺氨酸 (T3)。

研究领域：Vitamin D Related/Nuclear Receptor

作用靶点：Thyroid Hormone Receptor

In Vivo: Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 ａnd DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 ａnd DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion. L-Thyroxine (T4) ａnd Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps ａnd regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis ａnd flux responsible for excitation ａnd contractility, with L-Thyroxine ａnd Triiodothyronine modulating its pharmacological control ａnd secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine ａnd L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19). Rats treated with high doses of L-Thyroxine display a significant increase in both Triiodothyronine ａnd L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 ａnd p=0.004, respectively) ａnd a significant increase in L-Thyroxine levels when compared to the control values (p=0.03).

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